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Lovastatin

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    Lovastatin
  • Lovastatin
Cat No: 10010338
Chemicals - Miscellaneous Chemicals
Cayman
€34.00
Price is excluding VAT and does not include packaging neither shipping

A prodrug of lovastatin hydroxy acid; a potent and competitive inhibitor of HMG-CoA reductase (Kis = 1.4 and 0.6 nM for lovastatin and lovastatin hydroxy acid, respectively); reduces plasma cholesterol by 29% in dogs over a period of three weeks at a d...

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Territorial Availability: Available through Bertin Pharma only in Europe
Product Overview:
A prodrug of lovastatin hydroxy acid; a potent and competitive inhibitor of HMG-CoA reductase (Kis = 1.4 and 0.6 nM for lovastatin and lovastatin hydroxy acid, respectively); reduces plasma cholesterol by 29% in dogs over a period of three weeks at a dose of 8 mg/kg/day; suppresses TNF-induced NF-κB activation (IC50 ~ 15 µM),
Lovastatin is an HMG-CoA reductase inhibitor that was initially isolated from A. terreus. It is a prodrug of its more potent metabolite, lovastatin hydroxy acid (Item No. 10010339). Both competitively inhibit HMG-CoA reductase with Ki values of 1.4 and 0.6 nM for lovastatin and the open ring, hydroxy acid form, respectively. Lovastatin (8 mg/kg/day) reduces plasma cholesterol in dogs by 29% over a three week period. It also suppresses TNF-induced NF-κB activation (IC50 ~ 15 µM), which potentiates apoptosis in human myeloid leukemia cells and thus, may be useful in treating cancer. Formulations containing lovastatin were the first HMG-CoA reductase inhibitors to be used in the treatment of hypercholesterolemia.
Size: 5 mg
Shipping: wet ice
Stability: Store at -20 degrees; shelf life 730 days maximum after production
CAS Number: 75330-75-5
Molecular Formula: C24H36O5
SMILES: C[C@@H]1C[C@H](OC([C@@H](C)CC)=O)[C@@]2([H])C(C=C[C@H](C)[C@@H]2CC[C@@H]3C[C@@H](O)CC(O3)=O)=C1
Molecular Weight: 404.5
Formulation: A crystalline solid
Purity: ≥98%
Custom Code: 2932996560
UNSPSC code: 12352100

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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Cross selling for this product : Lovastatin There are 10 products.

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