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20-hydroxy Leukotriene B4

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    20-<wbr/>hydroxy Leukotriene B<sub>4</sub>
  • 20-<wbr/>hydroxy Leukotriene B<sub>4</sub>
Cat No: 20190
Chemicals - Prostaglandin/leukotriene/ Thromboxane
Cayman
€177.00
Price is excluding VAT and does not include packaging neither shipping

A metabolite of LTB4 in human neutrophils; inhibits LTB4-induced degranulation of human neutrophilis (Ki = 13.3 nM)
20-hydroxy LTB4 is a metabolite of LTB4 in human neutrophils. In human leukocytes, LTB4 is inactivated by the enzyme LTB4 20-hydroxylase...

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Territorial Availability: Available through Bertin Pharma only in Europe
Product Overview:
A metabolite of LTB4 in human neutrophils; inhibits LTB4-induced degranulation of human neutrophilis (Ki = 13.3 nM)
20-hydroxy LTB4 is a metabolite of LTB4 in human neutrophils. In human leukocytes, LTB4 is inactivated by the enzyme LTB4 20-hydroxylase. 20-hydroxy LTB4 is not only much less active (~5%) compared to LTB4 in causing degranulation of PMNL, but actually inhibits LTB4-induced degranulation of human neutrophils (Ki = 13.3 nM). However, 20-hydroxy LTB4 is as active as LTB4 in contracting parenchymal strips from guinea pig lung. 20-hydroxy LTB4 retains considerable ligand binding affinity at the BLT2 receptor, but does not appear to function as an agonist.
Size: 25 µg
Shipping: wet ice
Stability: Store at -20 degrees; shelf life 365 days maximum after production
CAS Number: 79516-82-8
Molecular Formula: C20H32O5
SMILES: OCCCCC/C=C\C[C@@H](O)/C=C/C=C/C=C\[C@@H](O)CCCC(O)=O
Molecular Weight: 352.5
Formulation: A solution in ethanol
Purity: ≥97%
Custom Code: 2937500000
UNSPSC code: 12352100
UN Number: UN1170

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