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Chrysomycin B

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    Chrysomycin B
  • Chrysomycin B
Cat No: 14189
Chemicals - Api/drug/substrate/ Analytical Standard
Cayman
€169.00
Price is excluding VAT and does not include packaging neither shipping

An antibiotic isolated from a strain of Streptomyces; suppresses the growth of transplantable tumors in mice, an effect that may be related to its ability to bind DNA; causes DNA damage in the human lung adenocarcinoma A549 cell line and inhibits topoi...

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Territorial Availability: Available through Bertin Pharma only in Europe
Product Overview:
An antibiotic isolated from a strain of Streptomyces; suppresses the growth of transplantable tumors in mice, an effect that may be related to its ability to bind DNA; causes DNA damage in the human lung adenocarcinoma A549 cell line and inhibits topoisomerase II
Chrysomycin B is an antibiotic isolated from a strain of Streptomyces. It differs from its analog chrysomycin A (Item No. 14188) by having a methyl, rather than vinyl, group in the 8-position of the chromophore. Like its analog, chrysomycin B suppresses the growth of transplantable tumors in mice, an effect that may be related to its ability to bind DNA. It also causes DNA damage in the human lung adenocarcinoma A549 cell line and inhibits topoisomerase II. Chrysomycin B is structurally very similar to gilvocarcin V, which promotes DNA cross-linking with histone 3 and GRP78 when photoactivated by near-UV light.
Size: 250 µg
Shipping: wet ice
Stability: Store at -20 degrees; shelf life 365 days maximum after production
CAS Number: 83852-56-6
Molecular Formula: C27H28O9
SMILES: O=C(O1)C2=C(C(OC)=CC(C)=C2)C3=C1C4=C(C5OC(C)C(O)C(C)(O)C5O)C=CC(O)=C4C(OC)=C3
Molecular Weight: 496.5
Formulation: A yellowish to greenish solid
Purity: ≥98%
Custom Code: 2907299000
UNSPSC code: 12352100

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