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Thromboxane B1

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    Thromboxane B<sub>1</sub>
  • Thromboxane B<sub>1</sub>
Cat No: 10006610
Chemicals - Prostaglandin/leukotriene/ Thromboxane
Cayman
€145.00
Price is excluding VAT and does not include packaging neither shipping

DGLA is one of the 20-carbon fatty acids that can be metabolized to PGs and TXs by COX-1/COX-2. The result of this metabolism in the human platelet yields TXB1. TXB1 is produced in small amounts when DGLA is added to washed suspensions of human platel...

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Territorial Availability: Available through Bertin Pharma only in Europe
Product Overview:
DGLA is one of the 20-carbon fatty acids that can be metabolized to PGs and TXs by COX-1/COX-2. The result of this metabolism in the human platelet yields TXB1. TXB1 is produced in small amounts when DGLA is added to washed suspensions of human platelets, while the major metabolism of this 1-series fatty acid is via 12-LO. However, when co-incubated with amounts of ethanol often found in intoxicated humans, the metabolism of DGLA shifts to an enhanced production of TXB1. Urinary TXB1 or its metabolites may thus be a specific biomarker of prior ethanol abuse.
Dihomo-g-linolenic acid (DGLA) is one of the 20-carbon fatty acids that can be metabolized to prostaglandins and thromboxanes (TXs) by cyclooxygenases 1 and 2 (COX-1/COX-2). The result of this metabolism in the human platelet yields TXB1. TXB1 is produced in small amounts when DGLA is added to washed suspensions of human platelets, while the major metabolism of this 1-series fatty acid is via 12-lipoxygenase. However, when co-incubated with amounts of ethanol often found in intoxicated humans, the metabolism of DGLA shifts to an enhanced production of TXB1. Urinary TXB1 or its metabolites may thus be a specific biomarker of prior ethanol abuse.
Size: 1 mg
Shipping: wet ice
Stability: Store at -20 degrees; shelf life 730 days maximum after production
CAS Number: 64626-32-0
Molecular Formula: C20H36O6
SMILES: O[C@@H]1[C@H](CCCCCCC(O)=O)[C@@H](/C=C/[C@@H](O)CCCCC)OC(O)C1
Molecular Weight: 372.5
Formulation: A solution in methyl acetate
Purity: >98%
Custom Code: 2937500000
UNSPSC code: 12352100
UN Number: UN1231

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Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

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