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5-PAHSA

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    5-PAHSA
  • 5-PAHSA
Cat No: 17043
Chemicals - Lipids / Fatty Acids
Cayman
€66.00
Price is excluding VAT and does not include packaging neither shipping

A FAHFA in which palmitic acid is esterified at the 5th carbon of hydroxy stearic acid; synthesized in vivo and regulated by fasting and high-fat feeding in mice; lowers ambient glycemia, improves glucose tolerance, and stimulates GLP-1 and insulin sec...

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Territorial Availability: Available through Bertin Pharma only in Europe
Product Overview:
A FAHFA in which palmitic acid is esterified at the 5th carbon of hydroxy stearic acid; synthesized in vivo and regulated by fasting and high-fat feeding in mice; lowers ambient glycemia, improves glucose tolerance, and stimulates GLP-1 and insulin secretion in mice
Branched fatty acid esters of hydroxy fatty acids (FAHFAs) are newly identified endogenous lipids regulated by fasting and high-fat feeding and associated with insulin sensitivity. 5-PAHSA is a FAHFA in which palmitic acid is esterified at the 5th carbon of hydroxy stearic acid. PAHSA isoforms are the most abundant forms of FAHFA identified in the adipose tissue of glucose tolerant AG4OX mice. PAHSAs are synthesized in vivo in both mice and humans and are regulated by fasting and high-fat feeding in mice. PAHSA levels correlate highly with insulin sensitivity and are reduced in adipose tissue and serum of insulin-resistant humans. PAHSA administration lowers ambient glycemia, improves glucose tolerance, and stimulates GLP-1 and insulin secretion in mice.
Size: 1 mg
Shipping: wet ice
Stability: Store at -20 degrees; shelf life 365 days maximum after production
CAS Number: 1481636-41-2
Molecular Formula: C34H66O4
SMILES: OC(CCCC(OC(CCCCCCCCCCCCCCC)=O)CCCCCCCCCCCCC)=O
Molecular Weight: 538.9
Formulation: A solution in methyl acetate
Purity: ≥95%
Custom Code: 2916151000
UNSPSC code: 12352100
UN Number: UN1231

Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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