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JWH 015-d7

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    JWH 015-<wbr/>d<sub>7</sub>
  • JWH 015-<wbr/>d<sub>7</sub>
Cat No: 10660
Chemicals - Forensic Regulated
Cayman
Price is excluding VAT and does not include packaging neither shipping

An internal standard for the quantification of JWH 015 by GC- or LC-MS
JWH 015-d7 contains seven deuterium atoms at the 1, 1', 2, 2', 3, 3, and 3 positions. It is intended for use as an internal standard for the quantification of JWH 015 by GC- or LC-m...

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Territorial Availability: Specific regulation - Please contact Bertin Pharma Customer Service
Technical Warning: Bertin Pharma restricts the sale of this product to licensed controlled substances laboratories and qualified academic research institutions. Please consult our General Terms and conditions of Sales for further details.
Special Advice: regulated item by French Administration ANSM / special delivery time and additional fees.
Product Overview:
An internal standard for the quantification of JWH 015 by GC- or LC-MS
JWH 015-d7 contains seven deuterium atoms at the 1, 1', 2, 2', 3, 3, and 3 positions. It is intended for use as an internal standard for the quantification of JWH 015 by GC- or LC-mass spectrometry (MS). JWH 015 is a selective aminoalkylindole peripheral cannabinoid (CB2) receptor agonist with Ki values of 13.8 and 383 nM for human recombinant CB2 and CB1 receptors, respectively. Using Theiler’s murine encephalomyelitis virus as a model for human multiple sclerosis, treatment with WIN 55,212-2, ACEA, and JWH 015 significantly improved the neurological deficit of established disease. JWH 015 was shown to reduce microglial activation, abrogate antigen expression, and decrease the number of CD4+ infiltrating T-cells in the spinal cord. In addition, JWH 015 reduces IFN-γ-induced up-regulation of CD40 expression in mouse microglial cells by interfering with the JAK/STAT1 pathway.
Size: 1 mg
Shipping: wet ice
Stability: Store at -20 degrees; shelf life 730 days maximum after production
CAS Number: 1346601-16-8
Molecular Formula: C23H14D7NO
SMILES: O=C(C1=C(C)N(C([2H])([2H])C([2H])([2H])C([2H])([2H])[2H])C2=C1C=CC=C2)C3=CC=CC4=C3C=CC=C4
Molecular Weight: 334.5
Formulation: A crystalline solid
Purity: ≥99% deuterated forms (d1-d7)
Custom Code: 2933497050
UNSPSC code: 12352100

Cayman Chemical's mission is to help make research possible by supplying scientists worldwide with the basic research tools necessary for advancing human and animal health. Our utmost commitment to healthcare researchers is to offer the highest quality products with an affordable pricing policy.

Our scientists are experts in the synthesis, purification, and characterization of biochemicals ranging from small drug-like heterocycles to complex biolipids, fatty acids, and many others. We are also highly skilled in all aspects of assay and antibody development, protein expression, crystallization, and structure determination.

Over the past thirty years, Cayman developed a deep knowledge base in lipid biochemistry, including research involving the arachidonic acid cascade, inositol phosphates, and cannabinoids. This knowledge enabled the production of reagents of exceptional quality for cancer, oxidative injury, epigenetics, neuroscience, inflammation, metabolism, and many additional lines of research.

Our organic and analytical chemists specialize in the rapid development of manufacturing processes and analytical methods to carry out clinical and commercial GMP-API production. Pre-clinical drug discovery efforts are currently underway in the areas of bone restoration and repair, muscular dystrophy, oncology, and inflammation. A separate group of Ph.D.-level scientists are dedicated to offering Hit-to-Lead Discovery and Profiling Services for epigenetic targets. Our knowledgeable chemists can be contracted to perform complete sample analysis for analytes measured by the majority of our assays. We also offer a wide range of analytical services using LC-MS/MS, HPLC, GC, and many other techniques.

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ISO Guide 34:2009

Cayman is a leader in the field of emerging drugs of abuse, providing high-purity Schedule I-V Controlled Substances to federally-licensed laboratories and qualified academic research institutions for forensic analyses. We are certified by ACLASS Accreditation Services with dual accreditation to ISO/IEC 17025:2005 and ISO Guide 34:2009.

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