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(±)12(13)-DiHOME

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    (±)12(13)-<wbr/>DiHOME
  • (±)12(13)-<wbr/>DiHOME
Cat No: 10009832
Chemicals - Lipids / Fatty Acids
Cayman
€43.00
Price is excluding VAT and does not include packaging neither shipping

A metabolite of (±)12(13)-EpOME
(±)12(13)-DiHOME is the diol resulting from the soluble epoxide hydrolase opening of (±)12(13)-EpOME (Item No. 52450). The mixture of the methyl ester of this diol and the 9,10 isomer are more cytotoxic than the methyl ...

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Territorial Availability: Available through Bertin Pharma only in Europe
Product Overview:
A metabolite of (±)12(13)-EpOME
(±)12(13)-DiHOME is the diol resulting from the soluble epoxide hydrolase opening of (±)12(13)-EpOME (Item No. 52450). The mixture of the methyl ester of this diol and the 9,10 isomer are more cytotoxic than the methyl ester epoxides in renal proximal tubular cells. However, in renal cortical mitochondria, the conversion of the epoxide to (±)12(13)-DiHOME appears to be part of the detoxification pathway that prevents mitochondrial dysfunction. This diol and the 9,10 isomer can be glucuronidated by human liver and intestinal microsomes as well as recombinant UGT2B7 through a hydroxyl group. High levels of LA-diol glucuronides have been found in the urine of humans with peroxisomal diseases. A mixture of the diols stimulates breast cancer cell proliferation in vitro and disrupts reproductive function in rats at relatively low concentrations.
Size: 25 µg
Shipping: wet ice
Stability: Store at -20 degrees; shelf life 365 days maximum after production
CAS Number: 263399-35-5
Molecular Formula: C18H34O4
SMILES: CCCCC[C@@H](O)[C@@H](O)C/C=C\CCCCCCCC(O)=O
Molecular Weight: 314.5
Formulation: A solution in methyl acetate
Purity: ≥98%
Custom Code: 2916196000
UNSPSC code: 12352100
UN Number: UN1231

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