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(?)-Neplanocin A - Chemicals - Miscellaneous Chemicals

Chemicals.Miscellaneous Chemicals
Reference 10584
Available through Bertin Pharma only in Europe
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Data

CAS number
72877-50-0
Shipping
wet ice
Molecular Formula
C11H13N5O3
Smiles
OCC1=C[C@@H](N2C=NC3=C2N=CN=C3N)[C@H](O)[C@@H]1O
Molecular Weight
263.3
Purity
≥98%
Stability
Store at -20 degrees; shelf life 730 days maximum
UNSPSC Code
1.23521E7

Description

Potently and irreversibly inactivates SAH hydrolase (Ki = 8.39 nM); has antitumor activity against mouse leukemia L1210 cells and broad-spectrum antiviral activity|S-Adenosylhomocysteine (SAH) hydrolase catalyzes the reversible hydrolysis of SAH to adenosine and homocysteine. The inhibition of SAH hydrolase causes the intracellular accumulation of SAH, elevating the ratio of SAH to S-adenosylmethionine (SAM) and inhibiting SAM-dependent methyltransferase. (-)-Neplanocin A potently and irreversibly inactivates SAH hydrolase (Ki = 8.39 nM). It has antitumor activity against mouse leukemia L1210 cells and broad-spectrum antiviral activity. Neplanocin A is more potent against vesicular stomatitis than the reversible SAH hydrolase inhibitor 3-deazaneplanocin (ID50 = 0.07 and 0.3 ?g/ml, respectively).

Documentation

Pricing

SizePrice (euros)Quantity  
1 mg521 €
 
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(?)-Neplanocin A 27/11/2014
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