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(?)-Neplanocin A - Chemicals - Miscellaneous Chemicals

Chemicals.Miscellaneous Chemicals
Reference 10584
Available through Bertin Pharma only in Europe
Product image

Data

CAS number
72877-50-0
Shipping
wet ice
Molecular Formula
C11H13N5O3
Smiles
OCC1=C[C@@H](N2C=NC3=C2N=CN=C3N)[C@H](O)[C@@H]1O
Molecular Weight
263.3
Purity
≥98%
Stability
Store at -20 degrees; shelf life 730 days maximum after production
UNSPSC Code
12352100
Synonyms
5R-(6-amino-9H-purin-9-yl)-3-(hydroxymethyl)-3-cyclopentene-1S,2R-diol
Supplied as
A crystalline solid
Description_article
(-)-Neplanocin A
Code_douanier
2933599550
Related_Products_ref
10009929|10583|10834|11102|13603|13828|9000372|9000786
Correlated Keywords
Cancer|Metabolism|Biochemicals|Inhibitors|S-adenosylhomocysteines, hydrolases, SAH, inhibitors, S-adenosylmethionines, SAM, methyltransferases, antitumor, antiviral, cancer, virus, methylation, Neplanocin, A, neplanocinA, anti-tumor

Description

Potently and irreversibly inactivates SAH hydrolase (Ki = 8.39 nM); has antitumor activity against mouse leukemia L1210 cells and broad-spectrum antiviral activity|S-Adenosylhomocysteine (SAH) hydrolase catalyzes the reversible hydrolysis of SAH to adenosine and homocysteine. The inhibition of SAH hydrolase causes the intracellular accumulation of SAH, elevating the ratio of SAH to S-adenosylmethionine (SAM) and inhibiting SAM-dependent methyltransferase. (?)-Neplanocin A potently and irreversibly inactivates SAH hydrolase (Ki = 8.39 nM). It has antitumor activity against mouse leukemia L1210 cells and broad-spectrum antiviral activity. Neplanocin A is more potent against vesicular stomatitis than the reversible SAH hydrolase inhibitor 3-deazaneplanocin (ID50 = 0.07 and 0.3 ?g/ml, respectively).

Documentation

Pricing

SizePrice (euros)Quantity  
500 µg274 €
1 mg521 €
5 mg2143 €
 
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(?)-Neplanocin A 22/12/2014
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