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(-)-Neplanocin A - Inhibitors

Inhibitors
Reference 10584
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Data

CAS number
72877-50-0
Molecular Formula
C11H13N5O3
Formulation
A crystalline solid
Purity
≥98%
Lambda Max
262 nm
Stability
2 years
Storage
-20°C
Shipping
Wet ice
Correlated Keywords
S-adenosylhomocysteines, hydrolases, SAH, inhibitors, S-adenosylmethionines, SAM, methyltransferases, antitumor, antiviral, cancer, virus, methylation, Neplanocin, A, neplanocinA, anti-tumor

Description

S-Adenosylhomocysteine (SAH) hydrolase catalyzes the reversible hydrolysis of SAH to adenosine and homocysteine. The inhibition of SAH hydrolase causes the intracellular accumulation of SAH, elevating the ratio of SAH to S-adenosylmethionine (SAM) and inhibiting SAM-dependent methyltransferase. (-)-Neplanocin A potently and irreversibly inactivates SAH hydrolase (Ki = 8.39 nM). It has antitumor activity against mouse leukemia L1210 cells and broad-spectrum antiviral activity. Neplanocin A is more potent against vesicular stomatitis than the reversible SAH hydrolase inhibitor 3-deazaneplanocin (ID50 = 0.07 and 0.3 μg/ml, respectively).

Related Products

Documentation

Pricing

SizePrice (euros)Quantity  
500 µg275 €
1 mg521 €
5 mg2143 €
 
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(-)-Neplanocin A 18/04/2014